Dyslipidaemia is a major risk factor for processes responsible for atherosclerotic cardiovascular disease (CVD). Cholesterol and triglycerides are insoluble in water and are transported in body fluids bound to small lipid-protein complexes called lipoproteins. Low density lipoprotein (LDL) in high concentration may lead to a build up of LDL cholesterol in the arterial tissue spaces, where it is subject to oxidative change and inflammatory process leading to the formation of atherosclerotic plaque which overtime time, may become unstable and rupture. High density lipoprotein (HDL), the good cholesterol, which transports LDL from the periphery to the liver to be broken down to bile acids, may oppose this process.
The high incidence of Dyslipidaemia in society today is due to environmental and lifestyle factors and especially the modern diet high in saturated fat and cholesterol. Genetic traits and other lifestyle factors such as the imbalance between energy intake and energy output, account for a different Dyslipidaemia featuring mildly elevated triglyceride and/or reduced HDL cholesterol, which is thought to be part of the insulin resistance syndrome associated with abdominal obesity, contributing to as much as 40% of cardiovascular disease.
Visceral abdominal fat is a specific source of excess fatty acids in the body, and this fat releases inflammatory mediators which can lead to atherosclerosis. Increased levels and increased turnover of fatty acids in the blood are found in abdominal obesity and are closely related to/cause insulin resistance. Consequently, there is an increased health risk if our waist measurement is greater than 94cm for males and 80cm for females. The waist/hip ratio is another important measurement together with body mass index (BMI) the latter limited by its inability to distinguish between fat and muscle, and between fat sites.
It is most important to cut down on saturated and trans-unsaturated fat which should provide less than 10% of energy requirement. Increase intake of monounsaturated, polyunsaturated and omega 3 fatty acids. One of the easiest ways to do this is to follow a Mediterranean style diet with limited quantities of red meat, processed foods, dairy, balanced by plentiful eating of fish, nuts, vegetables, fruit, pasta, olives and olive oil with moderate alcohol intake (red wine). For most people, the good fatty acids in this diet increase levels of HDL cholesterol, reduce total cholesterol and LDL cholesterol whilst the omega 3 fatty acids reduce triglyceride levels, reduce platelet activity and exert anti-inflammatory activity. The Lyon heart study of 600 patients who had suffered a previous heart attack had a 50% less mortality on a Mediterranean style diet than those on the low fat diet (the benefit was independent of drug therapy and cholesterol levels).
Regular exercise has been shown to increase HDL cholesterol by 5% and reduce LDL cholesterol by 10%
The Mediterranean style diet coupled with regular exercise offers a relatively easy way for most people to achieve their optimal weight overtime and to increase life expectancy
David Roach - McFaddens Pharmacy, Shop 43, Lower Level, Phone 9144 7011.
Back
to Top
|